Platelet Aggregation




Test Mnemonic

AGGPLP

CPT Codes

  • 82397 - QTY (8)
  • 85576 - QTY (11)
  • 85390 - QTY (1)

Includes

  • EPIN Max Aggreg
  • ATP Rel by Epineph
  • Epin 100 Max Aggreg
  • ATP Rel by Epineph 100
  • ADP Max Aggreg
  • ATP Rel by ADP
  • ADP 20 Max Aggreg
  • ATP Rel by ADP 20
  • Arach Max Aggreg
  • ATP Rel by Aracha
  • Collagen Max Aggreg
  • ATP Rel by Collagen
  • Thromboxane A2 Max Aggreg
  • ATP Rel by Thromboxane A2
  • ATP Rel by Thrombin
  • Risto 1500 Max Agg
  • Risto 1200 Max Agg
  • Risto 900 Max Agg
  • Risto 500 Max Agg

Performing Laboratory

n/a


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
30 mLWhole bloodSodium citrate (Lt. Blue) AmbientDo not centrifuge. Specimen must be delivered to testing lab within 3 hours after collection and before 2:00 p.m. Sample must not be drawn after noon. Draw 10 completely filled 2.7ml sodium citrate tubes of peripheral blood.
4 mLWhole bloodEDTA (Lavender) AmbientTHIS ASSAY REQUIRES MULTIPLE SPECIMEN TYPES.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
18 mL    Minimum is 6 completely filled 2.7mL sodium citrate tubes. 10 tubes are preferred to assure all testing can be completed.

Stability

Environmental Condition Description
Ambient Specimen should reach the lab within 3 hours of draw time
Frozenunacceptable
Refrigeratedunacceptable

Days Performed

Mon - Fri

Turnaround Time

1 - 3 days

Methodology

Name Description
Luminescence 
Optical Turbidimetric Aggregation 

Reference Range

ADP 20 Max Aggreg
Sex Age From Age To Type Range Range Unit
       Normal71-94% Max
ADP Aggregation
Sex Age From Age To Type Range Range Unit
   Years99 YearsNormal65-93% Max
Arach Max Aggreg
Sex Age From Age To Type Range Range Unit
   Years99 YearsNormal75-100% Max
ATP Rel by ADP
Sex Age From Age To Type Range Range Unit
       Normal0.1-1.3nM
ATP Rel by ADP 20
Sex Age From Age To Type Range Range Unit
       Normal0.1-1.4nM
ATP Rel by Aracha
Sex Age From Age To Type Range Range Unit
       Normal0.4-2.0nM
ATP Rel by Collagen
Sex Age From Age To Type Range Range Unit
       Normal0.4-1.7nM
ATP Rel by Epineph
Sex Age From Age To Type Range Range Unit
       Normal0.2-1.6nM
ATP Rel by Epineph 100
Sex Age From Age To Type Range Range Unit
       Normal0.2-1.7nM
ATP Release by Thromboxane A2
Sex Age From Age To Type Range Range Unit
       Normal0.2-1.4nM
Collagen Max Aggreg
Sex Age From Age To Type Range Range Unit
       Normal74-99% Max
Epin 100 Max Aggreg
Sex Age From Age To Type Range Range Unit
       Normal70-99% Max
EPIN Max Aggreg
Sex Age From Age To Type Range Range Unit
       Normal70-97% Max
Risto 1200 Max Agg
Sex Age From Age To Type Range Range Unit
       Normal76-100% Max
Risto 1500 Max Agg
Sex Age From Age To Type Range Range Unit
       Normal76-100% Max
Risto 500 Max Agg
Sex Age From Age To Type Range Range Unit
       Normal0-9% Max
Risto 900 Max Agg
Sex Age From Age To Type Range Range Unit
       Normal50-100% Max
Thrombin 1 Unit ATP Release
Sex Age From Age To Type Range Range Unit
       Normal>0.5 
Thromboxane A2 3 uM Max Aggregation
Sex Age From Age To Type Range Range Unit
       Normal58-93% Max

Special Info

3.2% sodium citrate is the preferred anticoagulant recommended by CLSI. Test will not be performed if platelet count is less than 100,000/uL. Patient preparation: discontinue aspirin, phenylbutazone, phenothiazines, thienopyridines and glycoprotein IIb/IIIa inhibitors (if ordered to study intrinsic platelet dysfunction) and antihistamines for seven days prior to test. Sample must be accompanied by the completed Clinical History Form for Hemostasis and Thrombosis Evaluation.

Clinical Info

Evaluation of platelet function including Glanzmann's thrombasthenia, Bernard Soulier Syndrome, storage pool disorders and some types of von Willebrand's disease. This assay is not recommended for monitoring the inhibitory effect of aspirin or clopidogrel. For this purpose, please order the Aspirin/Clopidogrel Resistance panel.