Platelet Aggregation
Test Mnemonic
AGGPLP
CPT Codes
- 82397 - QTY (8)
- 85576 - QTY (11)
- 85390 - QTY (1)
Includes
- EPIN Max Aggreg
- ATP Rel by Epineph
- Epin 100 Max Aggreg
- ATP Rel by Epineph 100
- ADP Max Aggreg
- ATP Rel by ADP
- ADP 20 Max Aggreg
- ATP Rel by ADP 20
- Arach Max Aggreg
- ATP Rel by Aracha
- Collagen Max Aggreg
- ATP Rel by Collagen
- Thromboxane A2 Max Aggreg
- ATP Rel by Thromboxane A2
- ATP Rel by Thrombin
- Risto 1500 Max Agg
- Risto 1200 Max Agg
- Risto 900 Max Agg
- Risto 500 Max Agg
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 30 mL | Whole blood | Sodium citrate (Lt. Blue) | Ambient | Do not centrifuge. Specimen must be delivered to testing lab within 3 hours after collection and before 2:00 p.m. Sample must not be drawn after noon. Draw 10 completely filled 2.7ml sodium citrate tubes of peripheral blood. | |
| 4 mL | Whole blood | EDTA (Lavender) | Ambient | THIS ASSAY REQUIRES MULTIPLE SPECIMEN TYPES. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 18 mL | Minimum is 6 completely filled 2.7mL sodium citrate tubes. 10 tubes are preferred to assure all testing can be completed. |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Specimen should reach the lab within 3 hours of draw time |
| Frozen | unacceptable |
| Refrigerated | unacceptable |
Days Performed
Mon - Fri
Turnaround Time
1 - 3 days
Methodology
| Name | Description |
|---|---|
| Luminescence | |
| Optical Turbidimetric Aggregation |
Reference Range
| ADP 20 Max Aggreg | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 71-94 | % Max | |||
| ADP Aggregation | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | 65-93 | % Max | |
| Arach Max Aggreg | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | 75-100 | % Max | |
| ATP Rel by ADP | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0.1-1.3 | nM | |||
| ATP Rel by ADP 20 | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0.1-1.4 | nM | |||
| ATP Rel by Aracha | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0.4-2.0 | nM | |||
| ATP Rel by Collagen | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0.4-1.7 | nM | |||
| ATP Rel by Epineph | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0.2-1.6 | nM | |||
| ATP Rel by Epineph 100 | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0.2-1.7 | nM | |||
| ATP Release by Thromboxane A2 | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0.2-1.4 | nM | |||
| Collagen Max Aggreg | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 74-99 | % Max | |||
| Epin 100 Max Aggreg | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 70-99 | % Max | |||
| EPIN Max Aggreg | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 70-97 | % Max | |||
| Risto 1200 Max Agg | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 76-100 | % Max | |||
| Risto 1500 Max Agg | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 76-100 | % Max | |||
| Risto 500 Max Agg | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0-9 | % Max | |||
| Risto 900 Max Agg | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 50-100 | % Max | |||
| Thrombin 1 Unit ATP Release | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | >0.5 | ||||
| Thromboxane A2 3 uM Max Aggregation | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 58-93 | % Max |
Special Info
3.2% sodium citrate is the preferred anticoagulant recommended by CLSI. Test will not be performed if platelet count is less than 100,000/uL. Patient preparation: discontinue aspirin, phenylbutazone, phenothiazines, thienopyridines and glycoprotein IIb/IIIa inhibitors (if ordered to study intrinsic platelet dysfunction) and antihistamines for seven days prior to test. Sample must be accompanied by the completed Clinical History Form for Hemostasis and Thrombosis Evaluation.
Clinical Info
Evaluation of platelet function including Glanzmann's thrombasthenia, Bernard Soulier Syndrome, storage pool disorders and some types of von Willebrand's disease. This assay is not recommended for monitoring the inhibitory effect of aspirin or clopidogrel. For this purpose, please order the Aspirin/Clopidogrel Resistance panel.