PM-Scl-100 Antibody, IgG by Immunoblot




Test Mnemonic

PM1AB

CPT Codes

  • 86235 - QTY (1)

LOINC ®

61120-2

Aliases

  • PM-1 Antibody
  • Polymyositis Associated Antibody

Includes

  • PM/Scl 100 Antibody, IgG

Performing Laboratory

ARUP


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLSerumSST (Gold) RefrigeratedTransfer 1 mL serum into standard aliquot tube.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.3 mL     

Stability

Environmental Condition Description
AmbientAfter separation from cells: 48 hours
FrozenAfter separation from cells: 1 month (avoid repeated freeze/thaw cycles)
RefrigeratedAfter separation from cells: 14 days

Days Performed

Tue, Thu, Sat

Turnaround Time

2 - 5 days

Methodology

Name Description
Immunoblot (IB), Qualitative 

Reference Range

PM-Scl Antibody
Sex Age From Age To Type Range Range Unit
       Negative 

Special Info

Contaminated, hemolyzed, or severely lipemic specimens will be rejected. This test is New York DOH approved.

Clinical Info

The presence of PM/Scl-100 IgG antibody along with a positive ANA IFA nucleolar pattern is associated with connective tissue diseases such as polymyositis (PM), dermatomyositis (DM), systemic sclerosis (SSc), and polymyositis/systemic sclerosis overlap syndrome. The clinical relevance of PM/Scl-100 IgG antibody with a negative ANA IFA nucleolar pattern is unknown. PM/Scl-100 is the main target epitope of the PM/Scl complex, although antibodies to other targets not detected by this assay may occur.