POC Microarray with Reflex to Chromosomes
Test Mnemonic
SNPHF
CPT Codes
- 88233 - QTY (1)
- 88262 - QTY (1)
- 81229 - QTY (1)
Aliases
- Chromosome Analysis
- Products of Conception
- SNP Array
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 10 mm square | Products of conception (POC) | Sterile container | Ambient | Ambient | Fresh tissue sample from the fetus, placenta, umbilical cord, amniotic membrane and chorionic membrane is accepted. Do not expose to formalin or other fixatives. Do not freeze (NOTE: DNA isolation can still be performed if the sample has been frozen). Place specimen in a sterile container containing RPMI, Hank's solution or sterile saline. Keep at room temperature; may refrigerate if specimen must be held overnight. Transport to the laboratory as soon as possible to ensure cell viability. |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Preferred |
| Refrigerated | Acceptable |
| Frozen | Unacceptable for chromosome analysis; DNA extraction will still be performed. |
Days Performed
7 days a week
Turnaround Time
14 days (excludes CC observed holidays)
Methodology
| Name | Description |
|---|---|
| Comparative genomic hybridization-oligo based | |
| Culture Karyotyping Microscopy |
Special Info
Upon receipt in the lab, a portion of the tissue sample will be cultured, in case chromosome analysis is required after the microarray has been completed. No charges will be applied if chromosome analysis is not required (CPT codes 88233, 88262, 88291). If there is sufficient material, a portion of the tissue sample may also be snap frozen. The majority of the sample will be used to isolate DNA, which will be used to perform chromosomal oligonucleotide and SNP based microarray (CPT code 81229).
Clinical Info
Evaluate the cause of miscarriage.