Serum/Plasma Qualitative Drug Detection Panel by LC-MS/MS
Test Mnemonic
SPDRG
CPT Codes
- 80324/G0480 - QTY (1)
- 80359/G0480 - QTY (1)
- 80355/G0480 - QTY (1)
- 80366/G0480 - QTY (1)
- 80347/G0480 - QTY (1)
- 80348/G0480 - QTY (1)
- 80349/G0480 - QTY (1)
- 80354/G0480 - QTY (1)
- 80356/G0480 - QTY (1)
- 80357/G0480 - QTY (1)
- 80358/G0480 - QTY (1)
- 80361/G0480 - QTY (1)
- 80370/G0480 - QTY (1)
- 80353/G0480 - QTY (1)
- 80362/G0480 - QTY (1)
- 80365/G0480 - QTY (1)
- 80377/G0480 - QTY (1)
- 80368/G0480 - QTY (1)
- 80373/G0480 - QTY (1)
- 80371/G0480 - QTY (1)
- 80323/G0480 - QTY (1)
- 83992/G0480 - QTY (1)
- 80372/G0480 - QTY (1)
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Frozen | Allow specimen to clot completely at room temperature. Centrifuge and transfer the serum to a standard transport tube within a recommended 2 hours of collection. Freeze serum for transport to performing laboratory. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Plasma | Green LiHep Nogel | Frozen | NO GEL. Centrifuge and transfer the plasma to a standard transport tube within a recommended 2 hours of collection. Freeze plasma for transport to performing laboratory. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 3 days |
| Refrigerated | 7 days |
| Frozen | 30 days |
Days Performed
1 day per week
Turnaround Time
1 - 14 days
Methodology
| Name | Description |
|---|---|
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
Reference Range
| 6-Monoacetylmorphine | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| 7-Aminoclonazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| 7-Aminoflunitrazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Acetyl fentanyl | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 1 | ng/mL | |||
| alpha-Hydroxyalprazolam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| alpha-Hydroxymidazolam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| alpha-Hydroxytriazolam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| alpha-PHP | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Alprazolam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Amphetamine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 10 | ng/mL | |||
| Baclofen | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 10 | ng/mL | |||
| Benzoylecgonine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Buprenorphine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 2 | ng/mL | |||
| Carfentanyl | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 1 | ng/mL | |||
| Carisoprodol | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Chlordiazepoxide | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Clonazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Codeine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Cyclobenzaprine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Delta-9-carboxy-THC | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 10 | ng/mL | |||
| Diazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Dihydrocodeine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| EDDP | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Eutylone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Fentanyl | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 1 | ng/mL | |||
| Flunitrazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 10 | ng/mL | |||
| Gabapentin | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 100 | ng/mL | |||
| Hydrocodone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Hydromorphone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Ketamine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Lorazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| MDA | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| MDEA | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| MDMA | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Meperidine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Methadone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Methamphetamine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Midazolam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Mitragynine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Morphine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Naloxone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| N-butylpentylone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Norbuprenorphine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 10 | ng/mL | |||
| Nordiazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Norfentanyl | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 1 | ng/mL | |||
| Norhydrocodone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Norketamine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Normeperidine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Noroxycodone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| O-Desmethyltramadol | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Oxazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Oxycodone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Oxymorphone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| para-Fluorofentanyl | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 1 | ng/mL | |||
| Phencyclidine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Phentermine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Pregabalin | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 100 | ng/mL | |||
| Speciociliatine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Tapentadol | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Temazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Tramadol | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Xylazine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Zolpidem | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL | |||
| Zolpidem phenyl-4-carboxylic acid | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < 5 | ng/mL |
Special Info
For medical purposes only; not valid for legal or forensic purposes.
Clinical Info
Qualitative panel to detect drug exposure from a targeted list of drugs and drug metabolites.
Clinical Limitation
Serum drug levels are generally lower in concentration and have shorter windows of detection compared to urine. A not detected result does not exclude the possibility of drug exposure.