Somatic TP53 Mutations in Whole Blood and Bone Marrow
Test Mnemonic
TP53MA
CPT Codes
- 81352 - QTY (1)
- 81351 - QTY (1)
Includes
- TP53 WBBM Specimen
- TP53 WBBM Interpretation
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Whole blood | EDTA (Lavender) | Refrigerated | Separate specimens must be submitted when multiple tests are ordered. Specimen source is required. | |
| 3 mL | Whole blood | Sodium heparin (Green) | Refrigerated | Separate specimens must be submitted when multiple tests are ordered. Specimen source is required. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Bone marrow | EDTA (Lavender) | Refrigerated | Separate specimens must be submitted when multiple tests are ordered. Specimen source is required. | |
| 3 mL | Bone marrow | Sodium heparin (Green) | Refrigerated | Separate specimens must be submitted when multiple tests are ordered. Specimen source is required. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1.5 mL | Whole Blood | ||||
| 1 mL | Bone Marrow |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | Whole Blood or Bone Marrow: 1 week |
| Ambient | Whole Blood or Bone Marrow: 72 Hours |
| Frozen | Unacceptable |
Days Performed
Varies
Turnaround Time
13 - 15 days
Methodology
| Name | Description |
|---|---|
| Massive Parallel Sequencing |
Special Info
Serum, plasma, grossly hemolyzed specimens or FFPE tissue is unacceptable. Specimen source is required. Separate specimens must be submitted when multiple tests are ordered.
Clinical Info
This testing is used to identify TP53 mutations with prognostic and/or therapeutic significance in hematologic malignancies. Gene tested: TP53 (NM_000546), all coding exons.