Voriconazole
Test Mnemonic
VORCON
CPT Codes
- 80285 - QTY (1)
LOINC ®
38370-3
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL | Serum | No additive (Red) | Refrigerated | Do not use serum separator tubes. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.2 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 15 days |
| Refrigerated | After separation from cells: 15 days |
| Frozen | After separation from cells: 60 days. |
Days Performed
3 days per week
Turnaround Time
1 - 4 days
Methodology
| Name | Description |
|---|---|
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
Reference Range
| Voriconazole | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | 1.0 - 5.9 | ug/mL |
Special Info
Collect immediately prior to next dose. Steady-state concentrations are found 5-7 days after initiation or dose adjustment. Do not collect in a gel separator tube. Centrifuge and transfer serum/plasma to a CCL tube and refrigerate within 1 hour of collection.
Clinical Info
Ranges are based on trough draw at steady-state concentration. Therapeutic: >0.9 µg/mL Prophylactic: >0.9 µg/mL Toxic: >5.9 µg/mL (Toxic values will not be called)
Clinical Limitation
Trough levels should generally not exceed 4.0 mcg/mL due to toxicity risk. However, the treating physician may target trough levels up to 6.0 mcg/mL in patients with severe infections without signs/symptoms of voriconazole toxicity. The treating physician must determine appropriate target levels/dosing based on the specific clinical situation. The therapeutic, prophylactic, and toxic ranges were based on the 2016 Infectious Disease Society of America's (IDSA) Clinical Practice Guidelines for the Management of Aspergillosis and Candidiasis and consultation from Cleveland Clinic's Department of Infectious Disease. Reference ranges and high/low indicator flags are provided as general guidelines only.