Hypercoagulation Diagnostic Interpretive Panel




Test Mnemonic

HYPER

CPT Codes

  • 86147 - QTY (3)
  • 85384 - QTY (1)
  • 85303 - QTY (1)
  • 86140 - QTY (1)
  • 81240 - QTY (1)
  • 85390 - QTY (1)
  • 85670 - QTY (1)
  • 85520 - QTY (1)
  • 85730 - QTY (1)
  • 85240 - QTY (1)
  • 85307 - QTY (1)
  • 85300 - QTY (1)
  • 85598 - QTY (1)
  • 85732 - QTY (1)
  • 85384 - QTY (1)
  • 85610 - QTY (1)
  • 86146 - QTY (2)

Aliases

  • Hypercoagulation Panel
  • Hyper Panel

Includes

  • PT Screen
  • Fibrinogen Activity
  • Beta-2 Glycoprotein Antibodies
  • FVIIIC
  • Antithrombin Assay
  • PROT S Clot
  • STACLOT LA
  • APC
  • Cardiolipin Antibodies
  • C-Reactive Protein
  • APTTSC
  • TT
  • ANTIXA
  • Protein C Functional
  • PTGEN

Performing Laboratory

Cleveland Clinic Laboratories


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
2 mLSerumSST (Gold) FrozenIndicate clearly which tube is plasma and which tube is serum. Submit Coagulation Consultation Patient History Form.
4 mLWhole bloodEDTA (Lavender) Refrigerated 
6 mLPlasmaSodium citrate (Lt. Blue)See noteCentrifuge, aliquot and freeze ASAP.Collection tubes must be filled to total fill volume. Inadequately filled and clotted tubes will be rejected. Non-testing sites: Centrifuge samples; Aliquot plasma into separate tubes and label with Epic Beaker labels, DO NOT POUR SPECIMENS TOGETHER. Specimens should be frozen (-20C or colder).

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
2 mL    Whole blood EDTA (Lavender)
1 mL    Serum
3 mL     Citrated plasma. NOTE: If only the minimum volume is received, some reflex testing may not be able to be performed.

Stability

Environmental Condition Description
AmbientMain campus: ACCEPTABLE for Whole Blood. (Must be delivered ambient to testing lab less than 4 hours post collection.) Non-Testing Sites: UNACCEPTABLE.
FrozenFor Non-Testing sites, Frozen Plasma is ACCEPTABLE. Centrifuge samples, then aliquot plasma into separate tubes and label with Epic Beaker labels. DO NOT COMBINE TUBES. Specimens should be frozen (-20° C or colder) and they are stable for 2 weeks. (6 months at -70° C)
RefrigeratedUnacceptable

Days Performed

Mon - Fri

Turnaround Time

3 - 5 days

Methodology

Name Description
Refer to individual components 

Special Info

Patient Preparation: Discontinue coumadin therapy for 7 days, heparin therapy for 2 days and thrombolytic therapy for 7 days prior to test, if possible. 3.2% sodium citrate is the preferred anticoagulant recommended by CLSI. Per Pathologist review, the following tests may be ordered and billed: Antithrombin III Antigen (85300), PTT Incubated Mixing Add On (85730, 85732 x2); Dilute Russell Viper Venom (85613); Platelet Neutralization (85597); Factor V Leiden (81241); Reptilase (85635); Fibrinogen Antigen (85385); D-Dimer (85379); Factor 8 chromogenic (85240); Sample must be accompanied by the completed Clinical History Form for Hemostasis and Thrombosis Evaluation and a medication list.

Clinical Info

Use in the evaluation of congenital or acquired disorders associated with a hypercoagulable state.