Search Results

2024 Cleveland Clinic Multispecialty Pathology Symposium – Register Now!

February 2023: Send-out Test Discontinuation – T3 Uptake (T3U)

Changes are effective February 21, 2023. If you have any questions about these changes, please contact Client Services for assistance.

December 2022: Changes to Acceptable Tube Type for Azole Anti-Fungal Therapeutic Drug Monitoring

All changes are effective December 20, 2022. If you have any questions about these changes, please contact Client Services for assistance.

Pathology Insights: Tumors of the Lung with Sanjay Mukhopadhyay, MD

In this video, Sanjay Mukhopadhyay, MD, briefly covers all lung tumor types listed in the new (2021) World Health Organization classification.

August 2022: Changes to C Telopeptide, Beta Cross Linked (CTELO)

Changes are effective as of September 6, 2022. For more information, please contact Client Services for assistance.

September 2022: Best Practice for Detecting Hyperhomocysteinemia – Homocysteine Testing—Not MTHFR Genotyping

If there is a clinical concern regarding hyperhomocysteinemia, CCL recommends Homocysteine testing (HOMCYS) in place of MTHFR genotyping.

Pathology Insights: Update on Small Round Cell Tumors with Scott Kilpatrick, MD

In this video, Dr. Kilpatrick provides context and WHO updates on the evolving classification of undifferentiated round cell sarcomas.

July 2022: Test Delay – Testosterone, Total and Free, Serum (TFTEST)

Effective July 18, 2022, Testosterone, Total and Free, Serum (TFTEST) testing is currently delayed for approximately three weeks.

July 2022: Changes to Sulfonylurea Hypoglycemics (SULFON)

Changes are effective as of July 5, 2022. For more information, please contact Client Services for assistance.

June 2022: Changes to Testosterone, Total and Free, Serum (TFTEST)

Changes are effective as of June 30, 2022. For more information, please contact Client Services for assistance.

Spinal Muscular Atrophy Testing Carrier Screening & Diagnostic Assay

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder, with an incidence of approximately 1 in 10,000 births.

May 2022: Immediate Test Discontinuation – Giardia lamblia IgG, IgA, IgM (GIAGAM)

Giardia lamblia IgG, IgA, IgM (GIAGAM) testing has been discontinued by the performing reference laboratory effective May 16, 2022.

May 2022: Test Discontinuation – Legionella Testing, LEGMAB & SLEGAB

LEGMAB and SLEGAB will be discontinued effective May 2, 2022. For more information, please contact Client Services for assistance.

Test Delay: Alpha 1 Antitrypsin Phenotype (A1APHE)

Test delay announcement effective April 14, 2022. For more information, please contact Client Services for assistance.

April 2022: Changes to CTELO, MECDS9, and K2 Testing

All changes are effective May 16, 2022. For more information, please contact Client Services for assistance.

March 2022: Changes to CBCDIF Result Reporting; Aldosterone Reference Intervals

Several changes impacting CBCDIF, ALDO, RENIND, and ALDREN testing are effective as of February 28, 2022. Read more for details.

February 2022: Immediate Test Discontinuation – Digoxin, Free, Serum (DIGFR)

Due to supply issues, Digoxin, Free, Serum (DIGFR) testing is temporarily discontinued effective February 28, 2022.

Estimated Glomerular Filtration Rate (eGFR) Updates

Recently released recommendations affecting a race variable in eGFR reporting have resulted in changes at Cleveland Clinic.

February 2022: Changes to Mycoplasma genitalium (MYGPCR)

Any additional information will be included in a future Technical Update. If you have any questions, please contact Client Services.

February 2022: Epic Beaker LIS Go-Live at Cleveland Clinic

On Saturday, February 26, 2022, Cleveland Clinic Laboratories will transition to the Epic Beaker laboratory information system (LIS).

January 2022: Changes to Specimen Requirements, Reference Ranges, and More

All changes are effective February 22, 2022. For more information, please contact Client Services for assistance.

December 2021: Test Delay – HIV-1 Antibody Confirmation by Western Blot (HIV1CO)

HIV-1 by Western Blot (HIV1CO) testing is experiencing extended test delays caused by a nationwide shortage of testing kits.

October 2021: Limited Availability of Amies Dual Swabs, ESwabs™

Intermittent supply chain interruptions are anticipated for Amies Dual Swabs and ESwabs™ through early 2022.

October 2021: TFTEST – Temporary Change in Performing Send-out Laboratory

Beginning October 25, 2021, Testosterone, Total and Free, Serum (TFTEST) will be temporarily sent to an alternate reference laboratory.

September 2021: New Test – Beta(β)-D-Glucan Assay

This FDA-approved assay diagnoses certain systemic fungal infections and supports anti-fungal therapy responses in hospitalized patients.

September 2021: Ziad Peerwani, MD Appointed as Medical Director of Cleveland Clinic Laboratories

Ziad Peerwani, MD has been appointed as the new Medical Director for Cleveland Clinic Laboratories, effective September 1, 2021.

Pathology Insights – Mammary Myofibroblastoma: A Practical Approach with Miglena Komforti, DO

Dr. Komforti discusses histopathologic findings, ancillary immunohistochemical stains, & clinical significance of mammary myofibroblastoma.

August 2021: Changes to Specimen Requirements, Reference Ranges, and Test Builds

All changes listed are effective August 16, 2021. Questions? Please contact Client Services at 800.628.6816.

July 2021: Test Menu Optimization & Discontinuations – MGLESE, MYSGRV, PARSYN

A recent review has identified tests that will be discontinued in favor of more simple, focused, and cost-effective testing options.

July 2021: Immediate Test Discontinuation – Hepatitis A Antibody, Total (AHAVT)

Due to vendor reagent being on backorder, AHAVT’s initially scheduled discontinuation on August 7 has been expedited to July 1, 2021.

Pathology Insights – Diagnosis of Oncocytic Salivary Gland Tumors with Mobeen Rahman, MD

The diagnosis of oncocytic salivary gland tumors can be challenging, especially on core needle biopsies; Dr. Mobeen Rahman discusses.

Syphilis Serological Testing

A reactive syphilis total/screen result indicates that a person has been exposed to T. pallidum subsp. pallidum at some point in their life.

June 2021: Send-Out Test Discontinuation – Complement Factor B (C3PA)

This test is no longer offered by the performing reference laboratory. At this time, there is no recommended replacement test.

CC-SIGN® Head & Neck Gene Fusion Next-Generation Sequencing Panel

This customized, 30-gene NGS panel is intended for use in the diagnosis and management of benign and malignant tumors of the head and neck.

Pathology Insights – NUT Carcinoma with Sanjay Mukhopadhyay, MD

In this video, Dr. Mukhopadhyay draws attention to an immunohistochemical profile that can serve as a tip-off to the correct diagnosis.

May 2021: Non-Sterile Aliquot Tubes – Back In Stock

As of May 25, 2021, Sarstedt aliquot tubes are back in stock. Laboratory supply orders can be placed by clients on the Supply Storefront.

May 2021: National Supply Shortage of Light Blue Coagulation Tubes

There is a severe nationwide shortage of light blue sodium citrate blood collection tubes used for coagulation laboratory tests.

Pathology Insights – Diagnosis of CD30+ T-cell Lymphoproliferative Disorders with Genevieve Crane, MD, PhD

The diagnosis of CD30+ T-cell lymphoproliferative disorder can present challenges. In this video, Dr. Genevieve Crane discusses.

April 2021: Changes to AIDYSA, ENCSER, PARNEO, LAMBRT, & MYGRAV Panels

Changes listed here are effective May 11, 2021. Questions? Please contact Client Services at 800.628.6816 for assistance.

Pathology Insights – Two Diagnoses in One Bone Marrow with Megan Nakashima, MD

Analysis of a bone marrow requires both careful morphologic examination as well as appropriate ancillary studies; Dr. Nakashima discusses.

Restrictions to PSA and β-HCG, Plasma Add-On Orders

Due to a potential for falsely-increased results from carryover on analytical laboratory instrumentation, add-on orders are restricted.

Pathology Insights – Diagnosing Microinvasive Breast Cancer with Miglena Komforti, DO

In the breast, the pathologic diagnosis of a small focus of invasion can be quite challenging; Dr. Miglena Komforti discusses.

February 2021: Inhibin B – Changes to Reference Ranges

A recent change increases the detection of inhibin B in all clinically relevant cases and expands the testing range to improve sensitivity.

Pathology Insights – Diagnosis of Metastatic Renal Cancer with Sean Williamson, MD

Pathologic diagnosis can be challenging in the setting of poorly-differentiated and metastatic renal cancer; Dr. Williamson discusses.

November 2020: Temporarily Unavailable – Stool Gastrointestinal Panel by PCR

Beginning November 13, 2020, Stool Gastrointestinal Panel by PCR (STGIPR) testing is temporarily unavailable to order from CCL.

COVID-19: Supply Constraints Affecting Enteric Bacterial Panel by PCR Testing

Due to supply constraints related to COVID-19, supplies for Enteric Bacterial Panel by PCR (STLPCR) testing are in extremely limited supply.

COVID-19: Unacceptable Specimen Transport Media for COVID-19 Testing

Due to incompatibilities with our COVID-19 testing laboratory equipment, Beaver Biomedical VTM and NEST Solution are not accepted by CCL.

COVID-19: Supply Shortages Impacting Gonorrhea, Chlamydia, and Trichomoniasis Testing

As a result of supply shortages, Cleveland Clinic Laboratories may periodically be unable to provide Aptima® Urine Specimen Collection Tubes.

August 2020: Update – Cytogenetic Karyotyping & Chromosomal Microarray Testing

Starting August 24, 2020, cytogenetic karyotyping and chromosomal microarray testing will temporarily be sent out to a reference laboratory.

August 2020: Anti-cardiolipin IgM, IgA, and IgG Reporting

Effective 9/3/2020, Anti-cardiolipin IgM, IgA, and IgG semi-quantitative enzyme immunoassays will be reported with updated reference ranges.